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SCR7 pyrazine

CAT: 0804-HY-107845-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107845-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine increases the efficiency of Cas9-mediated homology-directed repair (HDR) . SCR7 pyrazine induces cell apoptosis and has anticancer activity[1][2].
CAS Number
14892-97-8
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; CRISPR/Cas9; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/scr7-pyrazine.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC(NC2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N=C12)=S
Molecular Formula
C18H12N4OS
Molecular Weight
332.38
Precautions
H302
References & Citations
[1]Srivastava M, et al. An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression. Cell. 2012 Dec 21;151 (7) :1474-87.|[2]Lin C, et al. Increasing the Efficiency of CRISPR/Cas9-mediated Precise Genome Editing of HSV-1 Virus in Human Cells. Sci Rep. 2016 Oct 7;6:34531.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Int J Mol Sci. 2022 Jul 7;23 (14) :7518.|Int J Mol Sci. 2025 May 3;26 (9) :4361.|Nat Commun. 2025 Jul 15;16 (1) :6502.|Sci Adv. 2025 Jul 11;11 (28) :eadw1720.|Trends Biotechnol. 2025 Aug 30:S0167-7799 (25) 00314-2.|Trends Biotechnol. 2025 Jul;43 (7) :1743-1764.|University of Georgia. 2025.|Virology. 2025 May:606:110504.|BMC Biotechnol. 2021 Jul 27;21 (1) :45.|Cell Death Discov. 2025 Aug 23;11 (1) :402.|EMBO Rep. 2019 Mar;20 (3) :e46821.|J Genet Genomics. 2021 Feb 20;48 (2) :134-146.|J Immunol. 2020 Apr 1;204 (7) :1904-1918.|J Immunother Cancer. 2022 Jan;10 (1) :e003809.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.|Mol Ther Nucleic Acids. 2024 Jul 17;35 (3) :102274.|Onco Targets Ther. 2018 Aug 17:11:4945-4953.|Sens Actuators B Chem. 19 February 2022, 131598.|Stem Cell Res Ther. 2024 Dec 2;15 (1) :458.|Viruses. 2023 Nov 14;15 (11) :2256.

Chemical Information

Oprea1_571617
CAS Number14892-97-8
PubChem CID10688007
IUPAC Name6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one
Molecular FormulaC18H12N4OS
Molecular Weight332.4
XLogP2.9
Topological Polar Surface Area99
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count24
Formal Charge0
Complexity487
SMILES
C1=CC=C(C=C1)C2=NC3=C(NC(=S)NC3=O)N=C2C4=CC=CC=C4
InChI
InChI=1S/C18H12N4OS/c23-17-15-16(21-18(24)22-17)20-14(12-9-5-2-6-10-12)13(19-15)11-7-3-1-4-8-11/h1-10H,(H2,20,21,22,23,24)
InChIKey
GSRTWXVBHGOUBU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Oprea1_571617
CAS: 14892-97-8
CID: 10688007
Formula: C18H12N4OS
MW: 332.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight332.4
XLogP32.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass332.07318219
Monoisotopic Mass332.07318219
Topological Polar Surface Area99 Ų
Heavy Atom Count24
Formal Charge0
Complexity487
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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