MAT2A-IN-22

• Description:

  MAT2A-IN-22 (Compound 29-1) is a BBB-penetrable and orally active MAT2A inhibitor with an IC50 of 4 nM. MAT2A-IN-22 shows selectivity and inhibitory activity against MTAP-deficient cancer cell lines. MAT2A-IN-22 has anti-tumor effects[1].

• UNSPSC:

  12352005

• Target:

  Isotope-Labeled Compounds; Methionine Adenosyltransferase (MAT)

• Related Pathways:

  Epigenetics; Metabolic Enzyme/Protease; Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  O=C1[C@]2 (C3=CC (C (F) (F) F) =CC=C3C (NC ([2H]) ([2H]) [2H]) =N1) C4=CC=CN=C4CC2

• Molecular Formula:

  C18H11D3F3N3O

• Molecular Weight:

  348.34

• References & Citations:

  [1]Yang S, et al. Discovery of Novel Spirocyclic MAT2A Inhibitors Demonstrating High In Vivo Efficacy in MTAP-Null Xenograft Models. J Med Chem. 2025 Feb 13;68 (3) :3480-3494.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  2925330-18-1