MAT2A-IN-22

• Description :

  MAT2A-IN-22 (Compound 29-1) is a BBB-penetrable and orally active MAT2A inhibitor with an IC50 of 4 nM. MAT2A-IN-22 shows selectivity and inhibitory activity against MTAP-deficient cancer cell lines. MAT2A-IN-22 has anti-tumor effects[1].

• UNSPSC :

  12352005

• Target :

  Isotope-Labeled Compounds; Methionine Adenosyltransferase (MAT)

• Related Pathways :

  Epigenetics; Metabolic Enzyme/Protease; Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C1[C@]2(C3=CC(C(F)(F)F)=CC=C3C(NC([2H])([2H])[2H])=N1)C4=CC=CN=C4CC2

• Molecular Formula :

  C18H11D3F3N3O

• Molecular Weight :

  348.34

• References & Citations :

  [1]Yang S, et al. Discovery of Novel Spirocyclic MAT2A Inhibitors Demonstrating High In Vivo Efficacy in MTAP-Null Xenograft Models. J Med Chem. 2025 Feb 13;68 (3) :3480-3494.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [2925330-18-1]