STAT5-IN-3

CAT: 0804-HY-170837Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-170837Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer activity. STAT5-IN-3 blocks the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites and significantly reduces the expression of STAT5B protein, thereby inhibiting downstream gene transcription and blocking the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 holds significant value in overcoming chemotherapy resistance[1].
UNSPSC
12352005
Target
STAT
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Field of Research
Cancer
Smiles
CC(CC1)(C)C2=C(C=CC=C2C3=CN=C(N)N=C3)N1CCOC4=CC=C5C(C=CN5)=C4
Molecular Formula
C25H27N5O
Molecular Weight
413.51
References & Citations
[1]Polomski M, et al. Novel antileukemic compound with sub-micromolar potency against STAT5 addicted myeloid leukemia cells. Eur J Med Chem. 2025 Feb 15;284:117211.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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