STAT5-IN-3

• Description:

  STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer activity. STAT5-IN-3 blocks the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites and significantly reduces the expression of STAT5B protein, thereby inhibiting downstream gene transcription and blocking the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 holds significant value in overcoming chemotherapy resistance[1].

• UNSPSC:

  12352005

• Target:

  STAT

• Related Pathways:

  JAK/STAT Signaling; Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  CC(CC1)(C)C2=C(C=CC=C2C3=CN=C(N)N=C3)N1CCOC4=CC=C5C(C=CN5)=C4

• Molecular Formula:

  C25H27N5O

• Molecular Weight:

  413.51

• References & Citations:

  [1]Polomski M, et al. Novel antileukemic compound with sub-micromolar potency against STAT5 addicted myeloid leukemia cells. Eur J Med Chem. 2025 Feb 15;284:117211.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported