STAT1/3-IN-1

• Description:

  STAT1/3-IN-1 (Compound 6k) is a STAT1/3 phosphorylation inhibitor. STAT1/3-IN-1 inhibits the phosphorylation and nuclear translocation of STAT1/3. STAT1/3-IN-1 also inhibits inflammatory enzymes iNOS and COX-2. STAT1/3-IN-1 demonstrates anti-inflammatory effect (reduction of pro-inflammatory cytokines, including IL-1β, IL-6 and TNF-α) without significant cytotoxicity[1].

• UNSPSC:

  12352005

• Target:

  COX; Interleukin Related; NO Synthase; STAT

• Related Pathways:

  Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Purity:

  99.23

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  ClC1=C(N2C=C(C3=CC=CC(NC(C4=CN(C[C@@](OCC[C@H]5C)([H])N5C6=O)C6=C(OC)C4=O)=O)=C3)N=N2)C=CC=C1

• Molecular Formula:

  C28H25ClN6O5

• Molecular Weight:

  560.99

• References & Citations:

  [1]Hou X, et al. Synthesis of dolutegravir derivatives modified by 1,2,3-triazole structure and their anti-inflammatory activity in LPS-induced BV2 cells. Bioorg Med Chem Lett. 2024 Dec 16;117:130076.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  COX-2; IL-6; iNOS; STAT1; STAT3

• CAS Number:

  [2958649-56-2]