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STAT1/3-IN-1

CAT: 0804-HY-170621-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-170621-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STAT1/3-IN-1 (Compound 6k) is a STAT1/3 phosphorylation inhibitor. STAT1/3-IN-1 inhibits the phosphorylation and nuclear translocation of STAT1/3. STAT1/3-IN-1 also inhibits inflammatory enzymes iNOS and COX-2. STAT1/3-IN-1 demonstrates anti-inflammatory effect (reduction of pro-inflammatory cytokines, including IL-1β, IL-6 and TNF-α) without significant cytotoxicity[1].
CAS Number
2958649-56-2
UNSPSC
12352005
Target
COX; Interleukin Related; NO Synthase; STAT
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Purity
99.23
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C(N2C=C(C3=CC=CC(NC(C4=CN(C[C@@](OCC[C@H]5C)([H])N5C6=O)C6=C(OC)C4=O)=O)=C3)N=N2)C=CC=C1
Molecular Formula
C28H25ClN6O5
Molecular Weight
560.99
References & Citations
[1]Hou X, et al. Synthesis of dolutegravir derivatives modified by 1,2,3-triazole structure and their anti-inflammatory activity in LPS-induced BV2 cells. Bioorg Med Chem Lett. 2024 Dec 16;117:130076.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2; IL-6; iNOS; STAT1; STAT3

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