CDK4/9-IN-1

• Description :

  CDK4/9-IN-1 (Compound 29) is a selective dual CDK4/9 inhibitor with IC50 values of 23 nM and 12 nM, respectively. CDK4/9-IN-1 is promising for research of cancers[1].

• UNSPSC :

  12352005

• Target :

  CDK

• Related Pathways :

  Cell Cycle/DNA Damage

• Field of Research :

  Cancer

• Smiles :

  CN(C)C(C(N(C1CCCC1)C2=N3)=CC2=CN=C3N[C@@H]4CC[C@H](CC4)NCCO)=O

• Molecular Formula :

  C22H34N6O2

• Molecular Weight :

  414.54

• References & Citations :

  [1]Jiang C, et al. Elucidating Binding Selectivity in Cyclin-Dependent Kinases 4, 6, and 9: Development of Highly Potent and Selective CDK4/9 Inhibitors. J Med Chem. 2025 Jan 23;68 (2) :1499-1510.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDK4; CDK9

• CAS Number :

  [2577288-83-4]