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KB-208

CAT: 0804-HY-170506-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-170506-01Size:5 mg
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Description
KB-208 is a phagocytosis inhibitor that acts similarly to intravenous immunoglobulin (IVIG) . KB-208 improves immune thrombocytopenia (ITP) in a mouse model at a dose of 1 mg/kg. KB-208 does not affect other blood parameters and does not elevate serum biochemical markers of toxicity, and can be used in research in the field of immunity[1][2].
CAS Number
1282128-68-0
UNSPSC
12352005
Target
Others
Related Pathways
Others
Field of Research
Inflammation/Immunology
Concentration
10mM
Purity
98.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CC1CCN(CC1)C(C2=CC(C3=CC=CS3)=NN2C4=CC=CC=C4)=O)OC
Molecular Formula
C22H23N3O3S
Molecular Weight
409.50
References & Citations
[1]Loriamini M, et al. A novel small molecule phagocytosis inhibitor, KB-208, ameliorates ITP in mouse models with similar efficacy as IVIG. Transfusion. 2024 Dec;64 (12) :2233-2240.|[2]Aşık A, et al. Amcasertib Increases Apoptosis While Decreasing Invasive and Migrating Abilities in Breast Cancer Stem Cells[J]. Clinical and Experimental Health Sciences, 2024, 14 (3) : 800-806.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

methyl (1-{[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-5-yl]carbonyl}piperidin-4-yl)acetate
CAS Number1282128-68-0
PubChem CID52902668
IUPAC Namemethyl 2-[1-(1-phenyl-3-thiophen-2-ylpyrazole-5-carbonyl)piperidin-4-yl]acetate
Molecular FormulaC22H23N3O3S
Molecular Weight409.5
XLogP3.6
Topological Polar Surface Area92.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count29
Formal Charge0
Complexity576
SMILES
COC(=O)CC1CCN(CC1)C(=O)C2=CC(=NN2C3=CC=CC=C3)C4=CC=CS4
InChI
InChI=1S/C22H23N3O3S/c1-28-21(26)14-16-9-11-24(12-10-16)22(27)19-15-18(20-8-5-13-29-20)23-25(19)17-6-3-2-4-7-17/h2-8,13,15-16H,9-12,14H2,1H3
InChIKey
JBTAEQNNSPGXHO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of methyl (1-{[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-5-yl]carbonyl}piperidin-4-yl)acetate
CAS: 1282128-68-0
CID: 52902668
Formula: C22H23N3O3S
MW: 409.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight409.5
XLogP33.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass409.14601278
Monoisotopic Mass409.14601278
Topological Polar Surface Area92.7 Ų
Heavy Atom Count29
Formal Charge0
Complexity576
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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