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AMG-208

CAT: 0804-HY-12035-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12035-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG-208 is an orally active c-Met/RON dual selective inhibitor with an IC50 of 9 nM for c-Met. AMG-208 is a CYP3A4 inhibitor with an IC50 of 32 μM. AMG-208 has anti-cancer activity[1][2][3].
CAS Number
1002304-34-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
C-Met/HGFR; Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AMG-208.html
Purity
99.86
Solubility
DMSO : 3.33 mg/mL (ultrasonic)
Smiles
COC1=CC=C2C(OCC3=NN=C4N3N=C(C=C4)C5=CC=CC=C5)=CC=NC2=C1
Molecular Formula
C22H17N5O2
Molecular Weight
383.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Albrecht BK, et al. Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase. J Med Chem. 2008, 51 (10), 2879-2882.|[2]Boezio AA, et al. Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorg Med Chem Lett. 2009, 19 (22), 6307-6312.|[3]Liu X, et al. Developing c-MET pathway inhibitors for cancer therapy: progress and challenges. Trends Mol Med. 2010,16 (1), 37-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CYP3; Met

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