DHW-208

CAT: 0013-GTR19274002-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19274002-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

PI3K-IN-4 is a potent pan-PI3K inhibitor demonstrating high activity across three PI3K isoforms with picomolar IC50 values. It exhibits excellent inhibitory activity against PI3Kα (IC50 = 0.20 nM), PI3Kβ (IC50 = 2.99 nM), PI3Kδ (IC50 = 0.48 nM), and PI3Kγ (IC50 = 0.58 nM), but shows no significant activity against EGFR. By interfering with the PI3K/Akt signaling pathway, PI3K-IN-4 hinders cancer cell proliferation, blocks colony formation, and induces apoptosis (apoptosis) . This compound is applicable in research related to lung cancer, colon cancer, and breast cancer.

CAS Number

2269470-35-9

Smiles

O=S (=O) (NC=1C=C (C=NC1OC) C2=CC=C3N=CN=C (NC=4C=NN (C4) CCO) C3=C2) C5=CC=C (F) C=C5F

Molecular Formula

C25H21F2N7O4S

Molecular Weight

553.54

Storage Conditions

-20°C

Notes

For research use only.

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