PF-07265028

CAT: 0804-HY-170443-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-170443-01Size:5 mg
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Description
PF-07265028 is a selective hematopoietic progenitor kinase 1 (HPK1/MAP4K1) . PF-07265028 can be used in the research of cancer. PF-07265028 shows very potent cellular activity as measured by pSLP76 IC50 (17 nM) [1].
CAS Number
[2736458-30-1]
UNSPSC
12352005
Target
MAP4K
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.03
Smiles
CC[C@H](C1=NC(N2CCC[C@H]2C)=CC3=C1CN(C4=CC=CC(C5=NN=C6CC[C@@H](N56)C)=N4)C3=O)N
Molecular Formula
C26H32N8O
Molecular Weight
472.59
References & Citations
[1]Rebecca A Gallego, et al. Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer. J Med Chem. 2024 Dec 26;67 (24) :22002-22038.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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