SAL-0010042

• Description:

  SAL-0010042 is the inhibitor for Plasmodium phosphodiesterase β (PDEβ), that inhibits the hydrolysis of cAMP and cGMP (IC50=48.9 nM) in gametocytes, activates PKG, and inhibits the growth and development of Plasmodium (IC50 for 3D7 and Dd2 is 142 nM and 218 nM) . SAL-0010042 inhibits hPDE5 and hPDE6 with IC50 of 632 nM and 73 nM[1].

• UNSPSC:

  12352005

• Target:

  Parasite; Phosphodiesterase (PDE)

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Smiles:

  O=C1N=C(CC2=C(F)C=CC=C2)NC3=C1NN=C3C(C)C

• Molecular Formula:

  C15H15FN4O

• Molecular Weight:

  286.30

• References & Citations:

  [1]Gomez-Gonzalez PJ, et al., Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission. Sci Adv. 2024 Dec 6;10 (49) :eadq1383.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [521298-46-4]