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DIDS (sodium salt)

CAT: 0804-HY-D0086-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D0086-01Size:5 mg
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Description
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research[1][2][3][4].
CAS Number
67483-13-0
Product Name Alternative
MDL101114ZA
UNSPSC
12171500
Hazard Statement
H315, H317, H319, H330, H334, H335, H351, H412
Target
RAD51; VDAC
Type
Dye Reagents
Related Pathways
Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/DIDS_sodium_salt.html
Purity
99.13
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(N=C=S)=CC=C1/C=C/C2=CC=C(N=C=S)C=C2S(=O)(O[Na])=O)(O[Na])=O
Molecular Formula
C16H8N2Na2O6S4
Molecular Weight
498.48
Precautions
H315, H317, H319, H330, H334, H335, H351, H412
References & Citations
[1]Tsou CY, et al. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. Acta Physiol (Oxf) . 2014 Apr;210 (4) :799-810.|[2]Chen H, et al. Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages. Apoptosis. 2014 Dec;19 (12) :1712-26.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Isoform
VDAC1
Citation 01
Adv Sci (Weinh) . 2021 Nov;8 (21) :e2101936.|Autophagy. 2021 Nov;17 (11) :3592-3606.|Biochem Biophys Res Commun. 2021 Jun 30:560:52-58.|bioRxiv. 2023 Jul 3.|bioRxiv. 2024 July 10.|Br J Pharmacol. 2025 Aug;182 (16) :3923-3951.|Cancer Sci. 2020 Nov;111 (11) :4288-4302.|Cell Death Dis. 2024 Nov 9;15 (11) :811.|CNS Neurosci Ther. 2025 Apr;31 (4) :e70410.|FEBS Open Bio. 2022 Feb;12 (2) :516-522.|Front Pharmacol. 2023 Jun 26:14:1191692. |J Cell Mol Med. 2021 Jun;25 (11) :5238-5249.|Life Sci. 2020 Oct 15;259:118390.|Phytomedicine. 2024 May 28:130:155785.|Proc Natl Acad Sci U S A. 2025 Oct 7;122 (40) :e2502841122.|Sci Total Environ. 2024 Jun 30:946:174246.|SSRN. 2023 Nov 14.|Virulence. 2025 Dec;16 (1) :2490208.|Cell Death Discov. 2023 Jul 8;9 (1) :234.

Chemical Information

Disodium 4,4'-diisothiocyanato-2,2'-stilbenedisulfonate, (E)-

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CAS Number67483-13-0
PubChem CID5702690
IUPAC Namedisodium;5-isothiocyanato-2-[(E)-2-(4-isothiocyanato-2-sulfonatophenyl)ethenyl]benzenesulfonate
Molecular FormulaC16H8N2Na2O6S4
Molecular Weight498.5
Topological Polar Surface Area220
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Heavy Atom Count30
Formal Charge0
Complexity792
SMILES
C1=CC(=C(C=C1N=C=S)S(=O)(=O)[O-])/C=C/C2=C(C=C(C=C2)N=C=S)S(=O)(=O)[O-].[Na+].[Na+]
InChI
InChI=1S/C16H10N2O6S4.2Na/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24;;/h1-8H,(H,19,20,21)(H,22,23,24);;/q;2*+1/p-2/b2-1+;;
InChIKey
GEPAYBXVXXBSKP-SEPHDYHBSA-L
Chemical Structure
2D Structure
2D structure of Disodium 4,4'-diisothiocyanato-2,2'-stilbenedisulfonate, (E)-
CAS: 67483-13-0
CID: 5702690
Formula: C16H8N2Na2O6S4
MW: 498.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight498.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass497.90605924
Monoisotopic Mass497.90605924
Topological Polar Surface Area220 Ų
Heavy Atom Count30
Formal Charge0
Complexity792
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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