KF-52

• Description :

  KF-52 is a phosphofructokinase-1 (PFK1) inhibitor, with an IC50 of 2.1 μM. KF-52 significantly increases the OCR/ECAR (OCR: oxygen consumption rate; ECAR: extracellular acidification rate) ratio[1].

• CAS Number :

  [3104612-74-7]

• UNSPSC :

  12352005

• Target :

  Phosphatase

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Purity :

  98.94

• Smiles :

  [H][C@]1([C@H]([C@H]2C(O)=O)C(N(CCC3=C4NC5=C3C=CC=C5)[C@@H]4C(F)(F)F)=O)C[C@@]2(C=C1)[H]

• Molecular Formula :

  C21H19F3N2O3

• Molecular Weight :

  404.38

• References & Citations :

  [1]Ryo Kakehi, et al. Asymmetric Synthesis, Structure Determination, and Biologic Evaluation of Isomers of TLAM as PFK1 Inhibitors. ACS Med Chem Lett. 2024 Dec 4;16 (1) :59-63.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported