KF 18259

• Description :

  KF 18259 is a 5-HT3-receptor antagonist. KF 18259 inhibits the wrap-restraint stress-induced propulsive motility of the proximal and distal colon[1].

• CAS Number :

  [139094-48-7]

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Others

• Smiles :

  CN([C@@H](CC1)C2)[C@H]1C[C@@H]2OC(C(C3=CC=CC=C3N4CC(C)C)=CC4=O)=O.Cl

• Molecular Formula :

  C22H29ClN2O3

• Molecular Weight :

  404.93

• References & Citations :

  [1]Kishibayashi N, et al. Pharmacological properties of KF18259, a novel 5-HT3-receptor antagonist, in rats: inhibition of the distal colonic function. Jpn J Pharmacol. 1993 Dec;63 (4) :495-502.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT3 Receptor