KF-17625

• Description :

  KF-17625 is an orally active bronchodilator. KF-17625 can inhibit bronchoconstriction induced by Carbachol (HY-B1208), Histamine (HY-B1204), or Leukotriene D4 (HY-113456) . KF-17625 can inhibit canine tracheal phosphodiesterase (PDE) IV (IC50 = 12 μM) and Concanavalin-A (HY-P2149) -induced histamine release from rat mast cells (44% inhibition at 10 mM) . KF-17625 can be used for the researches of immunology and inflammation[1].

• UNSPSC :

  12352005

• Target :

  Histamine Receptor; Phosphodiesterase (PDE)

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C1C2=C(C3=C(N1C4=CC=CC=C4)N=CC=C3)NC=N2

• Molecular Formula :

  C15H10N4O

• Molecular Weight :

  262.27

• References & Citations :

  [1]Suzuki F, et al. New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4 (5H) -ones. J Med Chem. 1992 Dec 25;35 (26) :4866-74.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PDE4

• CAS Number :

  [139339-02-9]