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KF-17625

CAT: 0804-HY-105505Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-105505Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KF-17625 is an orally active bronchodilator. KF-17625 can inhibit bronchoconstriction induced by Carbachol , Histamine (HY-B1204), or Leukotriene D4 (HY-113456). KF-17625 can inhibit canine tracheal phosphodiesterase (PDE) IV (IC50 = 12 μM) and Concanavalin-A (HY-P2149) -induced histamine release from rat mast cells (44% inhibition at 10 mM). KF-17625 can be used for the researches of immunology and inflammation[1].
CAS Number
139339-02-9
UNSPSC
12352005
Target
Histamine Receptor; Phosphodiesterase (PDE)
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Inflammation/Immunology
Smiles
O=C1C2=C(C3=C(N1C4=CC=CC=C4)N=CC=C3)NC=N2
Molecular Formula
C15H10N4O
Molecular Weight
262.27
References & Citations
[1]Suzuki F, et al. New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4 (5H) -ones. J Med Chem. 1992 Dec 25;35 (26) :4866-74.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4

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