Epothilone B (Standard)

• Description :

  Epothilone B (Standard) is the analytical standard of Epothilone B. This product is intended for research and analytical applications. Epothilone B is a microtubule stabilizer with a Ki of 0.71μM. It acts by binding to the αβ-tubulin heterodimer subunit which causes decreasing of αβ-tubulin dissociation.

• Product Name Alternative :

  EPO 906 (Standard) ; Patupilone (Standard)

• UNSPSC :

  12352005

• Target :

  Antibiotic; Apoptosis; Bacterial; Fungal; Microtubule/Tubulin; Reference Standards

• Related Pathways :

  Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Others

• Field of Research :

  Cancer; Infection

• Smiles :

  O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C[C@]3([H])O[C@]3(C)CCC[C@H](C)[C@H](O)[C@@H](C)C1=O

• Molecular Formula :

  C27H41NO6S

• Molecular Weight :

  507.68

• References & Citations :

  [1]Regueiro-Ren A, et al. Synthesis and biological activity of novel epothilone aziridines. Org Lett. 2001 Aug 23;3 (17) :2693-6.|[2]Pagano A, et al. Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends. Biochem Pharmacol. 2012 Aug 15;84 (4) :432-43.|[3]Oehler C, et al. The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells. Neuro Oncol. 2011 Sep;13 (9) :1000-10.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [152044-54-7]