Epothilone A

• Description :

  Epothilone A is a competitive inhibitor of the binding of [3H] paclitaxel to tubulin polymers, with a Ki of 0.6-1.4 μM.

• Product Name Alternative :

  Epo A

• UNSPSC :

  12352005

• Target :

  Apoptosis; Microtubule/Tubulin

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Epothilone_A.html

• Purity :

  99.81

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C[C@]3([H])O[C@]3([H])CCC[C@H](C)[C@H](O)[C@@H](C)C1=O

• Molecular Formula :

  C26H39NO6S

• Molecular Weight :

  493.66

• References & Citations :

  [1]Kowalski RJ, et al. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol (R) ) . J Biol Chem. 1997 Jan 24;272 (4) :2534-41.|[2]Cheng KL, et al. Novel microtubule-targeting agents - the epothilones. Biologics. 2008 Dec;2 (4) :789-811.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [152044-53-6]