Epothilone A

• UNSPSC Description:

  Epothilone A is a competitive inhibitor of the binding of [3H] paclitaxel to tubulin polymers, with a Ki of 0.6-1.4 μM.

• Target Antigen:

  Apoptosis; Microtubule/Tubulin

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Epothilone_A.html

• Smiles:

  O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C[C@]3([H])O[C@]3([H])CCC[C@H](C)[C@H](O)[C@@H](C)C1=O

• Molecular Weight:

  493.66

• References & Citations:

  [1]Kowalski RJ, et al. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). J Biol Chem. 1997 Jan 24;272(4):2534-41.|[2]Cheng KL, et al. Novel microtubule-targeting agents - the epothilones. Biologics. 2008 Dec;2(4):789-811.

• Shipping Conditions:

  Blue Ice

• CAS Number:

  152044-53-6