Epothilone C

• Description :

  Epothilone C is a polyketide natural product. Epothilone C is produced by the combined action of one nonribosomal peptide synthetase (NRPS) and nine polyketide synthase (PKS) modules in a multienzyme system. Epothilone C can be used for tumor research[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Endogenous Metabolite

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C/C=C\CCC[C@H](C)[C@H](O)[C@@H](C)C1=O

• Molecular Formula :

  C26H39NO5S

• Molecular Weight :

  477.66

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Chen H, et al. Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit. Chem Biol. 2001 Sep;8 (9) :899-912. |[2]Mutka SC, et al. Heterologous production of epothilone C and D in Escherichia coli. Biochemistry. 2006 Jan 31;45 (4) :1321-30.|[3]Boddy CN, et al. Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. J Am Chem Soc. 2003 Mar 26;125 (12) :3428-9. Boddy CN, et al. Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. J Am Chem Soc. 2003 Mar 26;125 (12) :3428-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [186692-73-9]