Products for Research Use Only
RegisterLogin

NLRP3-IN-76

CAT: 0804-HY-170218Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-170218Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
NLRP3-IN-76 is an orally active NLRP3 inhibitor. NLRP3-IN-76 inhibits the production of NO, and the mRNA levels of proinflammatory cytokines (iNOS, IL-6, IL-1β and TNFα). NLRP3-IN-76 shows anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome and NF-κB signaling pathway. NLRP3-IN-76 ameliorates DSS -induced colitis and can be used for research of inflammatory bowel diseases (IBD).
UNSPSC
12352005
Target
Interleukin Related; NF-κB; NO Synthase; NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Smiles
COC1=CC=C(C2=NC(C(NNC(C3=NC=CC=C3)=O)=O)=CO2)C=C1
Molecular Formula
C17H14N4O4
Molecular Weight
338.32
References & Citations
[1]Sun Z, et al. Discovery of novel Bis-amide analogue ST12 for the treatment of inflammatory bowel diseases (IBD) by inhibiting NLRP3 inflammasome activation. Bioorg Chem. 2025 Jun 1;159:108402.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-162901NLRP3-IN-48
HY-159719NLRP3-IN-51
HY-156469NLRP3-IN-22
HY-163300NLRP3-IN-30
HY-148187-01NLRP3-IN-11
HY-153554-01NLRP3-IN-18
HY-151343NLRP3-IN-10
HY-162013NLRP3-IN-26
HY-162402NLRP3-IN-33
HY-145910NLRP3-IN-6

Alternative Products

CatalogName
GTR19258364-01NLRP3-IN-76
QY-E06005Human NLRP3 Inflammasome (NLRP3)
MBS8534011-01NLRP3
sc-51698SLP-76 (SLP-76/03)
BA6124-10NLRP3-IN-17

Popular Products