(R) - (+) -Tolvaptan

• Description :

  (R) - (+) -Tolvaptan ((R) - (+) -OPC-41061) is the (R) - (+) enantiomer of Tolvaptan (HY-17000) . Tolvaptan (OPC-41061) is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist[1][2].

• Product Name Alternative :

  (R) - (+) -OPC-41061

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Vasopressin Receptor

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Others

• Smiles :

  O=C(NC1=CC=C(C(N2CCC[C@@H](O)C3=CC(Cl)=CC=C32)=O)C(C)=C1)C4=CC=CC=C4C

• Molecular Formula :

  C26H25ClN2O3

• Molecular Weight :

  448.94

• Precautions :

  P264-P270-P330-P501

• References & Citations :

  [1]Yin L, et al. Efficient and promising asymmetric preparation of enantiopure tolvaptan via transfer hydrogenation with robust catalysts[J]. Tetrahedron: Asymmetry, 2010, 21 (19) : 2390-2393.|[2]Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95 (4) :324-36.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [331947-66-1]