(R) - (+) -Tolvaptan

• Description:

  (R) - (+) -Tolvaptan ((R) - (+) -OPC-41061) is the (R) - (+) enantiomer of Tolvaptan (HY-17000) . Tolvaptan (OPC-41061) is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist[1][2].

• Product Name Alternative:

  (R) - (+) -OPC-41061

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Vasopressin Receptor

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Others

• Smiles:

  O=C (NC1=CC=C (C (N2CCC[C@@H] (O) C3=CC (Cl) =CC=C32) =O) C (C) =C1) C4=CC=CC=C4C

• Molecular Formula:

  C26H25ClN2O3

• Molecular Weight:

  448.94

• Precautions:

  P264-P270-P330-P501

• References & Citations:

  [1]Yin L, et al. Efficient and promising asymmetric preparation of enantiopure tolvaptan via transfer hydrogenation with robust catalysts[J]. Tetrahedron: Asymmetry, 2010, 21 (19) : 2390-2393.|[2]Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95 (4) :324-36.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  331947-66-1