Tolvaptan

• Description :

  Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP) -induced platelet aggregation. Tolvaptan induces cell apoposis and affects cell cycle. Tolvaptan can be used for the research of hyponatremia[1][2].

• Product Name Alternative :

  OPC-41061

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy; Vasopressin Receptor

• Type :

  Reference compound

• Related Pathways :

  Autophagy; GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease; Endocrinology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Tolvaptan.html

• Purity :

  99.95

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(C1=CC=CC=C1C)NC2=CC=C(C(C)=C2)C(N3CCCC(C4=CC(Cl)=CC=C43)O)=O

• Molecular Formula :

  C26H25ClN2O3

• Molecular Weight :

  448.94

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95 (4) :324-36.|[2]El-Shabrawy M, et al. Protective effect of tolvaptan against cyclophosphamide-induced nephrotoxicity in rat models. Pharmacol Res Perspect. 2020 Oct;8 (5) :e00659.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  V2 Receptor

• CAS Number :

  [150683-30-0]