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Tolvaptan

CAT: 0804-HY-17000-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17000-01Size:5 mg
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Description
Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP) -induced platelet aggregation. Tolvaptan induces cell apoposis and affects cell cycle. Tolvaptan can be used for the research of hyponatremia[1][2].
CAS Number
[150683-30-0]
Product Name Alternative
OPC-41061
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Vasopressin Receptor
Type
Reference compound
Related Pathways
Autophagy; GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/Tolvaptan.html
Purity
99.95
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=CC=CC=C1C)NC2=CC=C(C(C)=C2)C(N3CCCC(C4=CC(Cl)=CC=C43)O)=O
Molecular Formula
C26H25ClN2O3
Molecular Weight
448.94
Precautions
H302, H315, H319, H335
References & Citations
[1]Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95 (4) :324-36.|[2]El-Shabrawy M, et al. Protective effect of tolvaptan against cyclophosphamide-induced nephrotoxicity in rat models. Pharmacol Res Perspect. 2020 Oct;8 (5) :e00659.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
V2 Receptor

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