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Tolvaptan phosphate ester (sodium)

CAT: 0804-HY-157220-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-157220-01Size:10 mg
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Description
Tolvaptan phosphate ester sodium, a prodrug of Tolvaptan , can be used in the study of cardiac edema. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP) -induced platelet aggregation[1][2].
CAS Number
942619-79-6
UNSPSC
12352005
Target
Vasopressin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tolvaptan-phosphate-ester-sodium.html
Purity
99.85
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 4.17 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)C=CC=C1)NC2=CC=C(C(C)=C2)C(N3C4=CC=C(C=C4C(CCC3)OP(O[Na])(O[Na])=O)Cl)=O
Molecular Formula
C26H24ClN2Na2O6P
Molecular Weight
572.88
References & Citations
[1]Hiroyuki Fujiki, et al. In vitro and in vivo pharmacological profile of OPC-61815, a water-soluble phosphate ester pro-drug of tolvaptan. J Pharmacol Sci. 2022 Nov;150 (3) :163-172.|[2]Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95 (4) :324-36.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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