Tolvaptan (Standard)
CAT:
804-HY-17000R
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Tolvaptan (Standard)
- CAS Number: 150683-30-0
- UNSPSC Description: Tolvaptan (Standard) is the analytical standard of Tolvaptan. This product is intended for research and analytical applications. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation. Tolvaptan induces cell apoposis and affects cell cycle. Tolvaptan can be used for the research of hyponatremia[1][2].
- Target Antigen: Autophagy; Vasopressin Receptor
- Type: Reference Standards
- Related Pathways: Autophagy;GPCR/G Protein
- Field of Research: Cardiovascular Disease; Endocrinology; Cancer
- Assay Protocol: https://www.medchemexpress.com/tolvaptan-standard.html
- Smiles: O=C(C1=CC=CC=C1C)NC2=CC=C(C(C)=C2)C(N3CCCC(C4=CC(Cl)=CC=C43)O)=O
- Molecular Weight: 448.94
- References & Citations: [1]Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95(4):324-36.|[2]El-Shabrawy M, et al. Protective effect of tolvaptan against cyclophosphamide-induced nephrotoxicity in rat models. Pharmacol Res Perspect. 2020 Oct;8(5):e00659.
- Shipping Conditions: Room temperature