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Tolvaptan-d7

CAT: 0804-HY-17000SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17000SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tolvaptan-d7 is the deuterium labeled Tolvaptan. Tolvaptan is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28μM for the inhibition of AVP-induced platelet aggregation[1][2].
CAS Number
1246818-18-7
UNSPSC
12352005
Target
Autophagy; Isotope-Labeled Compounds; Vasopressin Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; GPCR/G Protein; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology; Cancer
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C=C(C=C1)NC(C2=C(C([2H])=C([2H])C([2H])=C2[2H])C([2H])([2H])[2H])=O)C)N3C4=CC=C(Cl)C=C4C(CCC3)O
Molecular Formula
C26H18D7ClN2O3
Molecular Weight
455.98
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Friedman B, Cirulli J. Hyponatremia in critical care patients: Frequency, outcome, characteristics, and treatment with the vasopressin V (2) -receptor antagonist tolvaptan. J Crit Care. 2012 Aug 8.|[3]Inomata T. Tolvaptan (vasopressin receptor antagonist) .Nihon Rinsho. 2011 Nov;69 Suppl 9:408-11.|[4]Vaduganathan M, Gheorghiade M, Pang PS, Konstam MA, Zannad F, Swedberg K, Grinfeld L, Burnett JC Jr, Krasa HB, Zimmer C, Blair J, Ouyang J, Maggioni AP; EVEREST investigators. Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment. J Cardiovasc Med (Hagerstown) . 2012 Jul;13 (7) :415-22.|[5]Y Yamamura et al. OPC-41061, a Highly Potent Human Vasopressin V2-Receptor Antagonist: Pharmacological Profile and Aquaretic Effect by Single and Multiple Oral Dosing in Rats. J. Pharmacol. Exp. Ther. 1998, 287 (3), 860-867.|[6]RW Schrier et al. Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia. N Engl J Med 2006, 355, 2099-2112.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
V2 Receptor

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