Lu AF90103

• Description :

  Lu AF90103 (Compound 42e) is a methyl ester prodrug of compound 42d capable of penetrating the blood-brain barrier. Compound 42d acts as a partial agonist of the GluN1/GluN2B complex, exhibiting 24% efficacy, and has an EC50 value of 78 nM. Lu AF90103 plays an important role in neuropsychiatric diseases research[1].

• CAS Number :

  [2577196-14-4]

• UNSPSC :

  12352005

• Target :

  IGluR

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Smiles :

  CC1=C2C(C=C(S2)C(NC[C@@H](N)C(OC)=O)=O)=NC=C1

• Molecular Formula :

  C13H15N3O3S

• Molecular Weight :

  293.34

• References & Citations :

  [1]Erhad Ascic, et al. Advancements in NMDA Receptor-Targeted Antidepressants: From d-Cycloserine Discovery to Preclinical Efficacy of Lu AF90103. J Med Chem. 2024 Nov 28;67 (22) :20135-20155.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported