Lu AF90103

CAT: 0804-HY-169951Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-169951Size:1 Each
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Description
Lu AF90103 (Compound 42e) is a methyl ester prodrug of compound 42d capable of penetrating the blood-brain barrier. Compound 42d acts as a partial agonist of the GluN1/GluN2B complex, exhibiting 24% efficacy, and has an EC50 value of 78 nM. Lu AF90103 plays an important role in neuropsychiatric diseases research[1].
CAS Number
[2577196-14-4]
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC1=C2C(C=C(S2)C(NC[C@@H](N)C(OC)=O)=O)=NC=C1
Molecular Formula
C13H15N3O3S
Molecular Weight
293.34
References & Citations
[1]Erhad Ascic, et al. Advancements in NMDA Receptor-Targeted Antidepressants: From d-Cycloserine Discovery to Preclinical Efficacy of Lu AF90103. J Med Chem. 2024 Nov 28;67 (22) :20135-20155.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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