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TrxR1-IN-2

CAT: 0804-HY-168874Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168874Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TrxR1-IN-2 (Compound 6a) is a TrxR1 inhibitor that covalently binds to the Cys475 and Sec498 sites of TrxR1, thereby inhibiting TrxR1 activity and leading to redox homeostasis disruption, which triggers apoptosis and ferroptosis[1].
UNSPSC
12352211
Target
Apoptosis; Ferroptosis; TrxR
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C1O[C@@H]2C=C1C[C@H]3[C@@H](C(C(O3)=O)=C)[C@H](OC(NCCC)=O)/C=C(C)/C2
Molecular Formula
C19H23NO6
Molecular Weight
361.39
References & Citations
[1]Ren H, et al. Design of ROS-Triggered Sesquiterpene Lactone SC Prodrugs as TrxR1 Covalent Inhibitors for the Treatment of Non-Small Cell Lung Cancer[J]. Journal of Medicinal Chemistry, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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