TrxR1-IN-1

TrxR1-IN-1

• CAS Number: 3052303-04-2
• UNSPSC Description: TrxR1-IN-1 (Compound 5j) is a TrxR1 inhibitor (IC50: 8.8 μM). TrxR1-IN-1 has anticancer activity, with IC50s of MCF-7 (1.5 μM), HeLa (1.7 μM), BGC-823 (2.4 μM), SW-480 (2.8 μM), A549 (2.1 μM). TrxR1-IN-1 has antioxidant activity, and scavenges DPPH radical[1].
• Target Antigen: TrxR
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/trxr1-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N(C2=CC=C(CNC(C3=C(C=CC=C3)OC(C)=O)=O)C=C2)[Se]C4=CC=CC=C41
• Molecular Weight: 465.36
• References & Citations: [1]Zhong M, et al. Synthesis, cytotoxicity, antioxidant activity and molecular modeling of new NSAIDs-EBS derivatives. Eur J Med Chem. 2023 Jul 18;259:115662.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported