TrxR1-IN-B19

TrxR1-IN-B19

• CAS Number: 170950-29-5
• UNSPSC Description: TrxR1-IN-B19 (GO-Y015) (Compound B19) is a Curcumin (HY-N0005) derivative and colvalent TrxR1 inhibitor. TrxR1-IN-B19 inhibits TrxR1 enzyme activity to elevate oxidative stress, and then induce ROS-mediated ER Stress and mitochondrial dysfunction, subsequently resulting in cell cycle arrest and apoptosis[1].
• Target Antigen: Apoptosis; TrxR
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/trxr1-in-b19.html
• Solubility: 10 mM in DMSO
• Smiles: COC(C(OC)=CC=C1)=C1/C=C/C(/C=C/C2=C(C(OC)=CC=C2)OC)=O
• Molecular Weight: 354.40
• References & Citations: [1]Chen W,et al. Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation. Oncotarget. 2016 Mar 29;7(13):16593-609.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported