AurkA allosteric-IN-1

AurkA allosteric-IN-1

• UNSPSC Description: AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor (IC50: 6.50 μM) that inhibits the catalytic activity and non-catalytic functions of Aurora A. Aurora A regulates the assembly of the bipolar mitotic spindle and the fidelity of chromosome segregation during mitosis and has non-catalytic functions. AurkA allosteric-IN-1 blocks the interaction of AurkA with the activator TPX2 by binding to the Y pocket of AurkA[1].
• Target Antigen: Aurora Kinase
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-Kinase/protease
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/aurka-allosteric-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC=CC(C2=CC=NC=C2)=C1)NCC3=CC4=C(OCO4)C=C3
• Molecular Weight: 332.35
• References & Citations: [1]Lee H, et al. Discovery of N-benzylbenzamide-based allosteric inhibitors of Aurora kinase A. Bioorg Med Chem. 2024 Mar 15;102:117658.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported