13-TP

• Description :

  13-TP is an inhibitor of SARS-CoV-2. 13-TP effectively inhibits the SARS-CoV-2 central replication transcription complex (C-RTC, nsp12-nsp7-nsp82) catalyzed in vitro RNA synthesis. 13-TP completely inhibits the RdRp polymerization activity. 13-TP blocks the full extension of some of the primer RNA[1].

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis; SARS-CoV

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Field of Research :

  Infection

• Smiles :

  NC(N=C1NC)=NC2=C1N=CN2[C@@H]3O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@@H](O)[C@@]3(CF)F

• Molecular Formula :

  C12H19F2N6O12P3

• Molecular Weight :

  570.23

• References & Citations :

  [1]Liang L, et al. Discovery of a 2'-α-Fluoro-2'-β-C- (fluoromethyl) Purine Nucleotide Prodrug as a Potential Oral Anti-SARS-CoV-2 Agent. J Med Chem. 2025 Jan 23;68 (2) :1994-2007.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported