SOS1 activator 2

• Description :

  SOS1 activator 2 (Compound 65) is a benzimidazole derivative and a SOS1 activator. SOS1 activator 2 has a high binding affinity for SOS1 with a Kd of 9 nM. SOS1 activator 2 can regulate the Ras-ERK signaling pathway, which can be used in the study of cancer[1].

• UNSPSC :

  12352005

• Target :

  ERK; Ras; SOS1

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Smiles :

  FC1=C(C)C=C(CN2C3=C(N=C2N4CC5(C4)CNC5)C(C6=C(C)NN=C6C)=CC(Cl)=C3)C=C1C

• Molecular Formula :

  C26H28ClFN6

• Molecular Weight :

  478.99

• References & Citations :

  [1]Hodges TR, et al. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem. 2018 Oct 11;61 (19) :8875-8894.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2245237-54-9]