Squalamine (phosphate)

• Description :

  Squalamine phosphate (Compound ENT-01) is an orally active neuroprotective agent. Squalamine phosphate can displace α-Syn that is bound electrostatically to nerve cell membranes and prevent aggregation of α-Syn. Squalamine phosphate can be used for the research of neurological disease, such as Parkinson’s disease[1].

• Product Name Alternative :

  ENT 01; MSI-1256 (phosphate)

• UNSPSC :

  12352211

• Target :

  α-synuclein

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Smiles :

  O=P(O)(O)O.O[C@H]1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@]3([H])[C@H](C)CC[C@H](C(C)C)OS(=O)(O)=O)C)([H])[C@@]4([C@@](C[C@H](CC4)NCCCNCCCCN)([H])C1)C

• Molecular Formula :

  C34H68N3O9PS

• Molecular Weight :

  725.96

• References & Citations :

  [1]Camilleri M, et al. Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease : A Randomized Controlled Trial. Ann Intern Med. 2022 Dec;175 (12) :1666-1674.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1309370-82-8]