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Squalamine

CAT: 0804-HY-16468-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-16468-01Size:1 mg
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Description
Squalamine (MSI-1256) is an aminosterol compound with broad-spectrum antiviral activity. Squalamine makes cells less conducive to certain viral replication by altering the electrostatic interactions in the inner membrane of host cells. Squalamine also has antibacterial and antitumor activities. Squalamine has broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria, fungi and protozoa. Squalamine inhibits tumor-related angiogenesis and the growth of human breast cancer cells. Squalamine restores the function of enteric nervous system in Parkinson, s disease mouse models[1][2][3][4][5].
CAS Number
[148717-90-2]
Product Name Alternative
MSI-1256; ENT-01 (free acid)
UNSPSC
12352211
Target
Bacterial; Dengue Virus; FAK; HBV
Type
Natural Products
Related Pathways
Anti-infection; Protein Tyrosine Kinase/RTK
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Squalamine.html
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@](C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CC[C@H](C(C)C)OS(=O)(O)=O)C)([H])C[C@@H](NCCCNCCCCN)CC1
Molecular Formula
C34H65N3O5S
Molecular Weight
627.96
References & Citations
[4]West CL, et al. Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson's Disease. J Parkinsons Dis. 2020;10 (4) :1477-1491.|[5]Moore KS, et al. Squalamine: an aminosterol antibiotic from the shark. Proc Natl Acad Sci U S A. 1993 Feb 15;90 (4) :1354-8.|[1]Zasloff M, et al. Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential. Proc Natl Acad Sci U S A. 2011 Sep 20;108 (38) :15978-83.|[2]Djouhri-Bouktab L, et al. Squalamine ointment for Staphylococcus aureus skin decolonization in a mouse model. J Antimicrob Chemother. 2011 Jun;66 (6) :1306-10.|[3]Márquez-Garbán DC, et al. Squalamine blocks tumor-associated angiogenesis and growth of human breast cancer cells with or without HER-2/neu overexpression. Cancer Lett. 2019 May 1;449:66-75.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 3

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