JZL 184 (Standard)

CAT: 0804-HY-15249R-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-15249R-01Size:5 mg

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Description

JZL 184 (Standard) is the analytical standard of JZL 184. This product is intended for research and analytical applications. JZL 184 is a potent, selective and irreversible MAGL inhibitor that blocks 2-Arachidonoylglycerol (2-AG) hydrolysis in brain membranes (IC50 of 8 nM) . JZL 184 displays >300-fold selectivity for MAGL over FAAH[1][2].

CAS Number

1101854-58-3

UNSPSC

12352100

Hazard Statement

H301

Target

MAGL; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Neurological Disease

Purity

98.21

Smiles

OC(C1=CC=C(OCO2)C2=C1)(C3CCN(C(OC4=CC=C([N+]([O-])=O)C=C4)=O)CC3)C5=CC(OCO6)=C6C=C5

Molecular Formula

C27H24N2O9

Molecular Weight

520.49

Precautions

H301

References & Citations

[1]Long JZ, et al. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol. 2009 Jan;5 (1) :37-44.|[2]Pan B, et al. Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4- (dibenzo[d][1,3]dioxol-5-yl (hydroxy) methyl) piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. J Pharmacol Exp Ther. 2009 Nov;331 (2) :591-7.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Clinical Information

No Development Reported

Chemical Information

Jzl184

4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]-1-piperidinecarboxylic acid (4-nitrophenyl) ester is a member of benzodioxoles.

CAS Number	1101854-58-3
PubChem CID	25021165
IUPAC Name	(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
Molecular Formula	C27H24N2O9
Molecular Weight	520.5
XLogP	4.2
Topological Polar Surface Area	133
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	5
Heavy Atom Count	38
Formal Charge	0
Complexity	820

SMILES

C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]

InChI

InChI=1S/C27H24N2O9/c30-26(38-21-5-3-20(4-6-21)29(32)33)28-11-9-17(10-12-28)27(31,18-1-7-22-24(13-18)36-15-34-22)19-2-8-23-25(14-19)37-16-35-23/h1-8,13-14,17,31H,9-12,15-16H2

InChIKey

SEGYOKHGGFKMCX-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1101854-58-3

CID: 25021165

Formula: C27H24N2O9

MW: 520.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	520.5
XLogP3	4.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	5
Exact Mass	520.14818035
Monoisotopic Mass	520.14818035
Topological Polar Surface Area	133 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	820
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Catalog	Name
HY-15249-01	JZL 184
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HY-179148	EGFR-IN-184
HY-107591B	PF-184
HY-116461-01	ML-184
HY-W169940	NP-184
HY-159957-01	BAY-184

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