Products for Research Use Only
RegisterLogin

HC-030031 (Standard)

CAT: 0804-HY-15064R-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-15064R-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HC-030031 (Standard) is the analytical standard of HC-030031. This product is intended for research and analytical applications. HC-030031 is a potent and selective TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively.
CAS Number
349085-38-7
UNSPSC
12352100
Target
Reference Standards; TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C1C2=C(N=CN2CC(NC3=CC=C(C(C)C)C=C3)=O)N(C)C(N1C)=O
Molecular Formula
C18H21N5O3
Molecular Weight
355.39
References & Citations
[1]McNamara CR, et al. TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A. 2007 Aug 14;104 (33) :13525-30.|[2]Eid SR, et al. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain. 2008 Oct 27;4:48.|[3]Lennertz RC, et al. TRPA1 mediates mechanical sensitization in nociceptors during inflammation. PLoS One. 2012;7 (8) :e43597.|[4]Miyake T, et al. Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS. Nat Commun. 2016 Sep 15;7:12840.|[5]So K, et al. Hypoxia-induced sensitisation of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice. Sci Rep. 2016 Mar 17;6:23261.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

HC-030031

HC-030031 is an organic molecular entity. It has a role as a TRP channel modulator.

CAS Number349085-38-7
PubChem CID1150897
IUPAC Name2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-propan-2-ylphenyl)acetamide
Molecular FormulaC18H21N5O3
Molecular Weight355.4
XLogP1.7
Topological Polar Surface Area87.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity573
SMILES
CC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)C
InChI
InChI=1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)
InChIKey
HEQDZPHDVAOBLN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of HC-030031
CAS: 349085-38-7
CID: 1150897
Formula: C18H21N5O3
MW: 355.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight355.4
XLogP31.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass355.16443955
Monoisotopic Mass355.16443955
Topological Polar Surface Area87.5 Ų
Heavy Atom Count26
Formal Charge0
Complexity573
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-15064-01HC-030031
HY-100208RHC-067047 (Standard)
HY-157306HC-1310
HY-157231HC-5404
HY-P10431Hc-CATH
HY-160196-01HC-7366
HY-100208-01HC-067047
HY-112302-01HC-070
HY-112729-01HC-056456
HY-126856-01HC-Toxin

Alternative Products

CatalogName
MBS6109373-01HC 030031
C08966-50mgHC-030031

Popular Products