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HC-067047 (Standard)

CAT: 0804-HY-100208RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100208RSize:1 Each
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Description
HC-067047 (Standard) is the analytical standard of HC-067047. This product is intended for research and analytical applications. HC-067047 is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively[1].
CAS Number
883031-03-6
Target
Reference Standards; TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Cancer
Smiles
O=C(C1=C(C)N(CCCN2CCOCC2)C(C3=CC=CC=C3)=C1)NC4=CC=CC(C(F)(F)F)=C4
Molecular Formula
C26H28F3N3O2
Molecular Weight
471.51
References & Citations
[1]Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107 (44) :19084-9.|[2]Xing Y, et al. Decreased Expression of TRPV4 Channels in HEI-OC1 Cells Induced by High Glucose Is Associated with Hearing Impairment. Yonsei Med J. 2018 Nov;59 (9) :1131-1137.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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B7588-50HC 067047
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