(9R) -RO7185876

• Description:

  (9R) -RO7185876 (Compound example 16) is a γ-secretase inhibitor. (9R) -RO7185876 inhibits Αβ42 secretion. (9R) -RO7185876 can be used for the researches of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, dementia pugilistica or Down syndrome[1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β; γ-secretase

• Related Pathways:

  Neuronal Signaling; Stem Cell/Wnt

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Purity:

  99.51

• Smiles:

  FC(C(F)=C(C=C1)F)=C1[C@]2([H])C3=NC(N[C@H]4[C@@H]5CN(C6=NC=NC(C)=C6)C[C@H]4CC5)=NN3CCCC2

• Molecular Formula:

  C25H28F3N7

• Molecular Weight:

  483.53

• References & Citations:

  [1]Bjoern Bartels, et al. Bicyclic heteroaryl derivatives. WO2018083050. WIPO. 2018-05-11.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2226077-86-5]