RO7185876

• Description:

  RO7185876 is a potent and selective gamma secretase modulator as a potential research for Alzheimer's disease.

• UNSPSC:

  12352005

• Target:

  γ-secretase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; Stem Cell/Wnt

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ro7185876.html

• Purity:

  99.9

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  FC(C(F)=C(C=C1)F)=C1[C@@]2([H])C3=NC(N[C@H]4[C@@H]5CN(C6=NC=NC(C)=C6)C[C@H]4CC5)=NN3CCCC2

• Molecular Formula:

  C25H28F3N7

• Molecular Weight:

  483.53

• References & Citations:

  [1]Ratni H, et al. Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer's Disease. ACS Med Chem Lett. 2020 Apr 27;11 (6) :1257-1268.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2226038-71-5]