APTSTAT3-9R

• Target:

  Others|||STAT

• Related Pathways:

  Stem Cells|||JAK/STAT signaling|||Others

• Bioactivity:

  APTSTAT3-9R-9R is a STAT3 inhibitor (Ki: 231 nmol/L) . STAT3 has been reported to promote the proliferation, survival, metastasis, immune escape, as well as drug resistance of cancer cells, making it a promising target for various diseases. However, though multiple STAT3 inhibitors and its regulatory or effector pathway elements have been identified, bioactive agents are limited.

• Smiles:

  NC (CC1=CNC=N1) C (NC ([H]) C (NC (CC2=CC=CC=C2) C (NC (CCC (N) =O) C (NC (CC3=CNC4=C3C=CC=C4) C (N5C (C (NC ([H]) C (NC (CO) C (NC (CC6=CNC7=C6C=CC=C7) C (NC ([C@@H] (C) O) C (NC (CC8=CNC9=C8C=CC=C9) C (NC (CCC (O) =O) C (NC (CC (N) =O) C (NC ([H]) C (NC (CCCCN) C (NC (CC%10=CNC%11=C%10C=CC=C%11) C (NC ([C@@H

• Molecular Formula:

  C223H330N80O51

• Molecular Weight:

  4947.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C