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PF 04254644

CAT: 0804-HY-14510Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14510Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF 04254644 is an orally active c-Met inhibitor. PF 04254644 inhibits mesenchymal transfer factor/hepatocyte growth factor receptor. PF 04254644 induces myocardial degeneration in rats. PF 04254644 may be used in research on cardiovascular disease and cancer[1][2].
CAS Number
959584-91-9
UNSPSC
12352005
Target
C-Met/HGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Cardiovascular Disease
Smiles
C[C@@H](C1=CC2=C(N=CC=C2)C=C1)C3=NN=C4N3N=C(C5=CN(C)N=C5)C=C4
Molecular Formula
C20H17N7
Molecular Weight
355.40
References & Citations
[1]Cui JJ, et al. Lessons from (S) -6- (1- (6- (1-methyl-1H-pyrazol-4-yl) -[1,2,4]triazolo[4,3-b]pyridazin-3-yl) ethyl) quinoline (PF-04254644), an inhibitor of receptor tyrosine kinase c-Met with high protein kinase selectivity but broad phosphodiesterase family inhibition leading to myocardial degeneration in rats. J Med Chem. 2013 Sep 12;56 (17) :6651-65.|[2]Hu W, et al. A tyrosine kinase inhibitor-induced myocardial degeneration in rats through off-target phosphodiesterase inhibition. J Appl Toxicol. 2012 Dec;32 (12) :1008-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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