NS-398 (Standard)

• Description:

  NS-398 (Standard) is the analytical standard of NS-398. This product is intended for research and analytical applications. NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.

• UNSPSC:

  12352100

• Target:

  COX; Reference Standards

• Related Pathways:

  Immunology/Inflammation; Others

• Field of Research:

  Inflammation/Immunology; Cancer

• Smiles:

  CS(=O)(NC1=CC=C([N+]([O-])=O)C=C1OC2CCCCC2)=O

• Molecular Formula:

  C13H18N2O5S

• Molecular Weight:

  314.36

• References & Citations:

  [1]Futaki N, et al. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 1994 Jan;47 (1) :55-9.|[2]Futaki N, et al. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol. 1993 Jan;24 (1) :105-10.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  123653-11-2