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SN-398

CAT: 0804-HY-158230Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-158230Size:1 Each
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Description
SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC50=1.562 μM) . SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells[1].
CAS Number
[124623-00-3]
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sn-398.html
Smiles
O=C1N2C(C(C(C2)=C(C3=C4)CC)=NC3=CC(F)=C4O)=CC5=C1COC([C@]5(O)CC)=O
Molecular Formula
C22H19FN2O5
Molecular Weight
410.40
References & Citations
[1]Yoshikawa M, et al. Novel camptothecin analogues that circumvent ABCG2‐associated drug resistance in human tumor cells[J]. International journal of cancer, 2004, 110 (6) : 921-927.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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