SN-398

• Description :

  SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC50=1.562 μM) . SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells[1].

• UNSPSC :

  12352005

• Target :

  Topoisomerase

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sn-398.html

• Smiles :

  O=C1N2C(C(C(C2)=C(C3=C4)CC)=NC3=CC(F)=C4O)=CC5=C1COC([C@]5(O)CC)=O

• Molecular Formula :

  C22H19FN2O5

• Molecular Weight :

  410.40

• References & Citations :

  [1]Yoshikawa M, et al. Novel camptothecin analogues that circumvent ABCG2‐associated drug resistance in human tumor cells[J]. International journal of cancer, 2004, 110 (6) : 921-927.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [124623-00-3]