PF-06862309

• Description:

  PF-06862309 is a PF-06843195 (HY-131972) phosphate ester prodrug. PF-06862309 can be hydrolyzed to PF-06843195 in the presence of alkaline phosphatase. PF-06843195 is a highly selective PI3Kα inhibitor. PF-06862309 can be used for the study of breast cancer with ER+, HER2-, and PIK3CA mutations[1].

• UNSPSC:

  12352005

• Target:

  Drug Intermediate

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  O=[P](O)(O)OC[C@@](CN1C(OCC(F)F)=O)(CC1)NC2=NC(N3CCOCC3)=NC(C(C=N4)=CN=C4N)=C2F

• Molecular Formula:

  C20H26F3N8O7P

• Molecular Weight:

  578.44

• References & Citations:

  [1]Hengmiao Cheng, et al. Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195) . J Med Chem. 2021 Jan 14;64 (1) :644-661.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2067281-52-9]