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PF-06663195

CAT: 0804-HY-138013Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-138013Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-06663195 is a β-secretase (BACE1) inhibitor, with BACE1 CFA and BACE1 WCA IC50 values of 53 and 15 nM, respectively. PF-06663195 can be used for Alzheimer's disease research[1].
CAS Number
1621585-22-5
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Beta-secretase
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
FC[C@@H]1[C@@]2([H])[C@](N=C(S1)N)(C3=C(C=C(C=C3)F)F)CO[C@@H](C4=CC(C)=NO4)C2
Molecular Formula
C18H18F3N3O2S
Molecular Weight
397.41
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Michael A Brodney, et al. Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors. J Med Chem. 2015 Apr 9;58 (7) :3223-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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