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NOTA (Standard)

CAT: 0804-HY-134418R-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134418R-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NOTA (Standard) is the analytical standard of NOTA. This product is intended for research and analytical applications. NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect. NOTA can be used in multiple myeloma, breast cancer, lymphoma and myocardial infarction research[1][2][3][4][5][6].
CAS Number
56491-86-2
UNSPSC
12352100
Target
Radionuclide-Drug Conjugates (RDCs) ; Reference Standards
Related Pathways
Antibody-drug Conjugate/ADC Related; Others
Field of Research
Cancer; Cardiovascular Disease
Smiles
O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CC1
Molecular Formula
C12H21N3O6
Molecular Weight
303.31
References & Citations
[1]Singh AN, et al. Multivalent bifunctional chelator scaffolds for gallium-68 based positron emission tomography imaging probe design: signal amplification via multivalency. Bioconjug Chem. 2011;22 (8) :1650-1662. |[2]Liao AH, et al. Evaluation of 18F-labeled targeted perfluorocarbon-filled albumin microbubbles as a probe for microUS and microPET in tumor-bearing mice. Ultrasonics. 2013;53 (2) :320-327.|[3]Poschenrieder A, et al. [64Cu]NOTA-pentixather enables high resolution PET imaging of CXCR4 expression in a preclinical lymphoma model. EJNMMI Radiopharm Chem. 2017;2 (1) :2.|[4]Menichetti L, et al. MicroPET/CT imaging of αvβ₃ integrin via a novel ⁶⁸Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction. Eur J Nucl Med Mol Imaging. 2013 Aug;40 (8) :1265-74.|[5]Wang C, et al. ImmunoPET imaging of multiple myeloma with [68Ga]Ga-NOTA-Nb1053. Eur J Nucl Med Mol Imaging. 2021 Aug;48 (9) :2749-2760.|[6]Zhang Y, et al. Positron emission tomography imaging of CD105 expression with a 64Cu-labeled monoclonal antibody: NOTA is superior to DOTA. PLoS One. 2011;6 (12) :e28005.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

1,4,7-triazacyclononane-N,N',N''-triacetic acid

structure given in first source

CAS Number56491-86-2
PubChem CID124326
IUPAC Name2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid
Molecular FormulaC12H21N3O6
Molecular Weight303.31
XLogP-7.9
Topological Polar Surface Area122
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count21
Formal Charge0
Complexity320
SMILES
C1CN(CCN(CCN1CC(=O)O)CC(=O)O)CC(=O)O
InChI
InChI=1S/C12H21N3O6/c16-10(17)7-13-1-2-14(8-11(18)19)5-6-15(4-3-13)9-12(20)21/h1-9H2,(H,16,17)(H,18,19)(H,20,21)
InChIKey
JHALWMSZGCVVEM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,4,7-triazacyclononane-N,N',N''-triacetic acid
CAS: 56491-86-2
CID: 124326
Formula: C12H21N3O6
MW: 303.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight303.31
XLogP3-7.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass303.14303540
Monoisotopic Mass303.14303540
Topological Polar Surface Area122 Ų
Heavy Atom Count21
Formal Charge0
Complexity320
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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