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NOTA-AE105

CAT: 0804-HY-P5018-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P5018-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NOTA-AE105 is a PET ligand for the urokinase-type plasminogen activator receptor (uPAR) . NOTA-AE105 can be radiolabeled with 64Cu and 68Ga. Images of 68Ga-NOTA-AE105 and 64Cu-NOTA-AE105 demonstrate high contrast and clear tumor delineation. NOTA-AE105 can be used in the synthesis of radionuclide-conjugated compounds (RDCs) [1][2].
CAS Number
1820563-84-5
UNSPSC
12352209
Target
Radionuclide-Drug Conjugates (RDCs) ; Ser/Thr Protease
Type
Peptides
Related Pathways
Antibody-drug Conjugate/ADC Related; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nota-ae105.html
Purity
98.91
Solubility
DMSO : 66.67 mg/mL (ultrasonic) |DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CO)C(O)=O)[C@@H](NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](CCCNC(N)=N)NC([C@@H](CO)NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](CC(O)=O)NC(CN(CCN2CC(O)=O)CCN(CC2)CC(O)=O)=O)=O)CC3CCCCC3)=O)=O)=O)=O)CC(C=C4)=CC=C4O)=O)=O)CC5=CNC6=CC=CC=C56
Molecular Formula
C72H102N16O20
Molecular Weight
1511.68
References & Citations
[1]Risør LM, et al. Prognostic Value of Urokinase-Type Plasminogen Activator Receptor PET/CT in Head and Neck Squamous Cell Carcinomas and Comparison with 18F-FDG PET/CT: A Single-Center Prospective Study. J Nucl Med. 2022 Aug;63 (8) :1169-1176. |[2]Persson M, et al. uPAR is a promising new imaging biomarker in glioblastoma[J]. Journal of Nuclear Medicine, 2015.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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