NOTA

CAT: 0804-HY-134418-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-134418-01Size:5 mg
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Description
NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect. NOTA can be used in multiple myeloma, breast cancer, lymphoma and myocardial infarction research[1][2][3][4][5][6].
CAS Number
[56491-86-2]
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Radionuclide-Drug Conjugates (RDCs)
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nota.html
Purity
98.0
Solubility
H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CC1
Molecular Formula
C12H21N3O6
Molecular Weight
303.31
Precautions
H315, H319
References & Citations
[1]Singh AN, et al. Multivalent bifunctional chelator scaffolds for gallium-68 based positron emission tomography imaging probe design: signal amplification via multivalency. Bioconjug Chem. 2011;22 (8) :1650-1662. |[2]Liao AH, et al. Evaluation of 18F-labeled targeted perfluorocarbon-filled albumin microbubbles as a probe for microUS and microPET in tumor-bearing mice. Ultrasonics. 2013;53 (2) :320-327.|[3]Poschenrieder A, et al. [64Cu]NOTA-pentixather enables high resolution PET imaging of CXCR4 expression in a preclinical lymphoma model. EJNMMI Radiopharm Chem. 2017;2 (1) :2.|[4]Menichetti L, et al. MicroPET/CT imaging of αvβ₃ integrin via a novel ⁶⁸Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction. Eur J Nucl Med Mol Imaging. 2013 Aug;40 (8) :1265-74.|[5]Wang C, et al. ImmunoPET imaging of multiple myeloma with [68Ga]Ga-NOTA-Nb1053. Eur J Nucl Med Mol Imaging. 2021 Aug;48 (9) :2749-2760.|[6]Zhang Y, et al. Positron emission tomography imaging of CD105 expression with a 64Cu-labeled monoclonal antibody: NOTA is superior to DOTA. PLoS One. 2011;6 (12) :e28005.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RDC Bifunctional Chelator

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