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NOTA-COG1410

CAT: 0804-HY-P10220Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10220Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NOTA-COG1410 forms triggering receptor expressed on myeloid cells 2 (TREM2) targeting ligand. NOTA-COG1410 is capable of being labelled with 68Gallium (68Ga) for discovery and diagnosis of digestive system tumors through positron emission tomography/computed tomography (PET/CT) . NOTA-COG1410 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) [1].
CAS Number
2914099-35-5
UNSPSC
12352209
Target
Radionuclide-Drug Conjugates (RDCs) ; TREM receptor
Type
Peptides
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nota-cog1410.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C)C(N[C@@H](CO)C(NC(C)(C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(NC(C)(C)C(N[C@@H](CCCCNC(CN(CCN(CC1)CC(O)=O)CCN1CC(O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C
Molecular Formula
C76H140N24O19
Molecular Weight
1694.07
References & Citations
[1]Shi D, et al., Synthesis and Evaluation of 68Ga-NOTA-COG1410 Targeting to TREM2 of TAMs as a Specific PET Probe for Digestive Tumor Diagnosis. Anal Chem. 2022 Mar 8;94 (9) :3819-3830.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
RDC Peptide; TREM-2

Chemical Information

Nota-cog1410
CAS Number2914099-35-5
PubChem CID171360030
IUPAC Name2-[4-[2-[[(5S)-5-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-acetamidopropanoyl]amino]-3-hydroxypropanoyl]amino]-2-methylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-6-aminohexanoyl]amino]-4-methylpentanoyl]amino]-2-methylpropanoyl]amino]-6-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethyl]-7-(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid
Molecular FormulaC76H140N24O19
Molecular Weight1694.1
XLogP-7.4
Topological Polar Surface Area681
Hydrogen Bond Donor Count22
Hydrogen Bond Acceptor Count25
Rotatable Bond Count56
Heavy Atom Count119
Formal Charge0
Complexity3380
SMILES
C[C@@H](C(=O)N[C@@H](CO)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](CCCCNC(=O)CN1CCN(CCN(CC1)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N)NC(=O)C
InChI
InChI=1S/C76H140N24O19/c1-43(2)35-53(61(78)108)90-67(114)54(36-44(3)4)91-65(112)51(24-20-28-85-74(81)82)88-66(113)52(22-16-18-26-83-58(103)39-98-29-31-99(40-59(104)105)33-34-100(32-30-98)41-60(106)107)94-71(118)75(11,12)96-69(116)56(38-46(7)8)92-64(111)49(21-15-17-25-77)87-63(110)50(23-19-27-84-73(79)80)89-68(115)55(37-45(5)6)95-72(119)76(13,14)97-70(117)57(42-101)93-62(109)47(9)86-48(10)102/h43-47,49-57,101H,15-42,77H2,1-14H3,(H2,78,108)(H,83,103)(H,86,102)(H,87,110)(H,88,113)(H,89,115)(H,90,114)(H,91,112)(H,92,111)(H,93,109)(H,94,118)(H,95,119)(H,96,116)(H,97,117)(H,104,105)(H,106,107)(H4,79,80,84)(H4,81,82,85)/t47-,49-,50-,51-,52-,53-,54-,55-,56-,57-/m0/s1
InChIKey
BXRZFVPFNYKKBH-ITJFCMOYSA-N
Chemical Structure
2D Structure
2D structure of Nota-cog1410
CAS: 2914099-35-5
CID: 171360030
Formula: C76H140N24O19
MW: 1694.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1694.1
XLogP3-7.4
Hydrogen Bond Donor Count22
Hydrogen Bond Acceptor Count25
Rotatable Bond Count56
Exact Mass1693.07265833
Monoisotopic Mass1693.07265833
Topological Polar Surface Area681 Ų
Heavy Atom Count119
Formal Charge0
Complexity3380
Isotope Atom Count0
Defined Atom Stereocenter Count10
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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