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CP-394531

CAT: 0804-HY-125627Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-125627Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CP-394531 is an efficient and highly selective non-steroidal glucocorticoid receptor (GR) antagonist, with a Ki value of 0.1 nM. CP-394531 has a weak binding to androgen receptor (AR) (Ki = 130 nM), and has almost no effect on progesterone receptor (PR) and estrogen receptors (ERα, ERβ) . CP-394531 completely blocks the half-maximal agonistic effect induced by Dexamethasone (HY-14648G), with a Kif of 4.1 nM. CP-394531 can be used to study various diseases such as diabetes, obesity, depression, neurodegenerative diseases, glaucoma and Cushing's disease[1].
CAS Number
[305822-63-3]
UNSPSC
12352005
Target
Androgen Receptor; Glucocorticoid Receptor
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Neurological Disease; Metabolic Disease
Smiles
O[C@@]1(C#CCl)C[C@@]2([H])CCC3=C(C=CC(O)=C3)[C@]2(CC4=CC=CC=C4)CC1
Molecular Formula
C23H23ClO2
Molecular Weight
366.88
References & Citations
[1]Morgan BP, et al. Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists. J Med Chem. 2002 Jun 6;45 (12) :2417-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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