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AR-HO47108

CAT: 0804-HY-124742Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124742Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AR-HO47108 is an orally active reversible Na+/K+ ATPase inhibitor. AR-HO47108 reversibly blocks the final step of gastric acid secretion by competitively binding to the potassium ion binding site of the Na+/K+ ATPase in the gastric wall cells. AR-HO47108 can be used for research on diseases related to excessive gastric acid secretion, such as peptic ulcers[1].
CAS Number
248281-68-7
UNSPSC
12352005
Target
Na+/K+ ATPase
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Smiles
O=C(C1=CN2C(C(NCC3=C(C)C=CC=C3CC)=C1)=NC(C)=C2C)N
Molecular Formula
C20H24N4O
Molecular Weight
336.43
References & Citations
[1]Abelö A, et al. Application of a combined effect compartment and binding model for gastric acid inhibition of AR-HO47108: a potassium competitive acid blocker, and its active metabolite AR-HO47116 in the dog. Eur J Pharm Sci. 2006 Oct 1;29 (2) :91-101.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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