LMP-420

CAT: 0804-HY-124665Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-124665Size:1 Each
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Description
LMP-420 is a selective tumor necrosis factor-α (TNF-α) inhibitor. LMP-420 reduces the release of pro-inflammatory cytokines (e.g., IL-1β, IL-2), inducing the expression of anti-inflammatory cytokine IL-10 and anti-apoptotic molecules SOCS-1 and Mn-SOD. LMP-420 also downregulates chemokines (e.g., IP-10, MCP-1) to reduce immune cell infiltration. LMP-420 is promising for research of type 1 diabetes mellitus, inflammatory diseases (e.g., colitis), and HIV-Mycobacterium tuberculosis coinfection[1].
CAS Number
[473870-63-2]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Interleukin Related; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Infection; Metabolic Disease; Inflammation/Immunology
Smiles
ClC1=C2N=CN(CCCCCB(O)O)C2=NC(N)=N1
Molecular Formula
C10H15BClN5O2
Molecular Weight
283.52
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Angaswamy N, et al. LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A. Cell Transplant. 2012;21 (6) :1285-96.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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